![(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester](https://nudgeserver.mycafe24.com/wp-content/uploads/2023/08/D474245.png "(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester 1"){kind=small}
(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester
- Catalogue No.: IM066913
- CAS No.: 168958-19-8
- Mol. Formula: C12H19NO4
Description
| Catalogue Number | IM066913 |
| CAS No. | 168958-19-8 |
| Chemical Name | (1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester |
| Synonyms | (1R-trans)–4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester; (R)-t-Butyl (3-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate; |
| Molecular Formula | C12H19NO4 |
| Molecular Weight | 241.28 |
| Storage | Room Temperature, under inert atmosphere |
| Solubility | Methanol |
| Applications | (1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Category | Building Blocks; Nucleic Acid; Carbohydrates; |
Note: All Products are stable to be shipped at room temperature, unless otherwise specified.
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