Dopal (>80%)

Catalogue No.: IM070533
CAS No.: 5707-55-1
Mol. Formula: C₈H₈O₃

Description

Catalogue Number	IM070533
CAS No.	5707-55-1
Chemical Name	Dopal (>80%)
Synonyms	3,4-Dihydroxy-α-tolualdehyde; 3,4-Dihydroxybenzeneacetaldehyde; Homoprotocatechualdehyde; (3,4-Dihydroxyphenyl)acetaldehyde; 2-(3,4-Dihydroxyphenyl)acetaldehyde
Molecular Formula	C₈H₈O₃
Molecular Weight	152.15
Appearance	Pale Brown to Very Dark Brown Thick Oil to Sticky Solid
Storage	-20°C, Hygroscopic
Solubility	DMSO (Slightly), Methanol (Slightly)
Stability	Air Sensitive, Hygroscopic
Applications	Dopal is a product of Dopamine (CAT# D533780) catabolism by monoamine oxidase and may be further oxidized to 3,4-Dihydroxyphenylacetic Acid (CAT# D454250) via aldehyde dehydrogenase. DOPAL can also be reduced to Hydroxy Tyrosol (CAT# H977000) via cytosolic aldehyde or aldose reductase. DOPAL is harmful to nigrostriatal DA terminals and contributes to the profound putamen DA deficiency found in Parkinson's disease. Cytosolic and mitochondrial aldehyde dehydrogenase (ALDH) isoenzymes deficiency in mice results in increased levels of DOPAL, causing neurodegeneration and motor dysfunction also associated with Parkinson's disease.
Category	Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;

Note: All Products are stable to be shipped at room temperature, unless otherwise specified.